Topic 7: Nucleic Acids
2.6: Structure of DNA and RNA
7.1: DNA structure and Replication
Essential Ideas: (2.6) The structure of DNA allows for efficient storage of genetic information.
(7): The structure of DNA is ideally suited to its function.
2.6.U1 The nucleic acids DNA and RNA are polymers of nucleotides.
2.6.U2 DNA differs from RNA in the number of strands present, the base composition and the type of pentose.
2.6.U3 DNA is double helix made of two antiparallel strands of nucleotides linked by hydrogen bonding between complementary base pairs.
2.6.S1 Drawing simple diagrams of the structure of single nucleotides of DNA and RNA, using circles, pentagons, and rectangles to represent phosphates, pentoses, and bases.
Lesson 1: Structure of DNA / RNA
Activity: Model building
Video: Nucleic Acids (Bozeman Science)
Video: Structure of DNA (What does 5 ' (prime) to 3' (prime) mean?)
Hand-outs (to go on class composition notebook)
2. DNA structure information
7.1.S1: Analysis of results of the Hershey and Chase experiment providing evidence that DNA is the genetic material
7.1.A1: Rosalind Franklin and Maurice Wilkins’ investigation of DNA structures by X-ray diffraction
7.1.NOS: Making careful observations-Rosalind Franklin’s X-ray diffraction provided crucial evidence that DNA is a double helix.
2.6.A1: Crick and Watson’s elucidation of the structure of DNA using model making.
2.6.NOS: Using models as representation of the real world- Crick and Watson used model making to discover the structure of DNA
Lesson 2: DNA structure-the evidence
Link: DNA structure labeling diagram
Video: Using models to figure out the structure of DNA
Video (Rosalind Franklin)
Video (Franklin as remembered by her sister)
Video (Franklin as remember by Watson)
Extra: Nucleosome animation. Can you describe how DNA interacts with nucleosomes to promote DNA packaging into chromosomes?
Lesson 3: DNA Structure (continued)
1. DBQ: Chargaff's data p. 107 Blue Parrot Book
2. Visualizing Nucleosomes (Link).
Link: DNA Structure video (MIT)
Lesson 4: Exploration of DNA replication
- FGIK Guide (linked file)
Link: Replication video (crash course)
Link: DNA Replication video
Link: DNA replication video
Link: Graphic summary of key players and mechanism: Replication
Lesson 5: Replication
Replication review/Quiz debrief
Slides-Meselson and Stahl
Lesson 6: Technologies that came from our understanding of DNA replication
Lesson 7: Transcription and Translation
Slides (Central dogma: transcription and translation)
Link: Anatomy of a gene
Link: Summary of learning objectives
Link: Practice exam question (transcription)
Lesson 8: Transcription & Translation; Gene Expression
Link: Universal Codon chart
Link: Function finders-Protein Profiles
Slides (Gene expression and regulation: Coding vs non-coding DNA)
Lesson 9: Individual study
1. HL: Read Topic 7.3 Translation. Use attached document to make sure you learn all of the
stages. (Link: Summary of learning objectives )
2. Exam questions:
SL: Complete practice exam questions, page 2, top question parts A-C).
HL: Complete page 1 (top question parts A-B AND page 2 top question parts A-C)
3. Practice protein coding activity (function finders)
4. Complete lab reflections (due tuesday).
Link: Practice Exam (linked here)
Lesson 10: Individual Study
Slides (HL-tRNA, Epigenome)